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Published on: January 14, 2014
Dynamic FET PET Imaging of a "Butterfly" IDH-Wildtype Anaplastic Astrocytoma
Norbert Galldiks1,2,3, Anna Brunn4, Gereon R Fink1,2
1From the Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne.
Abstract:
A variety of neoplastic and nonneoplastic conditions involve the corpus callosum, which may result in a "butterfly" appearance on conventional MRI. Typically, that pattern shows a bilateral and heterogeneous contrast enhancement of the lesion, occasionally with central nonenhancing areas indicating intralesional necrosis. In contrast, anaplastic gliomas may show only minimal or even a lack of contrast enhancement on MRI. We here report neuroimaging findings in a 69-year-old man with a "butterfly" pattern on dynamic FET [O-(2-[F]-fluoroethyl)-L-tyrosine] PET and the diagnosis of an anaplastic astrocytoma (WHO grade III; IDH-1/-2 wildtype, no 1p/19q co-deletion) but without typical MRI contrast enhancement.
