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Updated: Jan 21, 2026

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Negative-pressure pulmonary edema after laparoscopic appendectomy.

Wei Chao Chang1

  • 1At the time this article was written, Wei Chao Chang practiced in the Department of Surgery at MedStar Good Samaritan Hospital in Baltimore, Md. He now practices in the Department of Surgery at Greater Baltimore Medical Center. The author has disclosed no potential conflicts of interest, financial or otherwise.

JAAPA : Official Journal of the American Academy of Physician Assistants
|July 27, 2019
PubMed
Summary

Negative-pressure pulmonary edema (NPPE) is a rare but serious condition causing lung fluid buildup due to airway obstruction. This case highlights NPPE occurring after a common laparoscopic appendectomy surgery.

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Area of Science:

  • Medicine
  • Pulmonology
  • Anesthesiology

Background:

  • Negative-pressure pulmonary edema (NPPE) is a rare clinical condition characterized by acute-onset bilateral pulmonary interstitial edema.
  • It arises from substantial negative intrathoracic pressure during forceful inspiratory efforts against an obstructed upper airway.
  • Postoperative NPPE, though infrequent, poses significant risks if not promptly identified and managed.

Observation:

  • This report details a case of a patient experiencing NPPE postoperatively.
  • The complication occurred subsequent to a laparoscopic appendectomy procedure.

Findings:

  • The patient developed acute bilateral pulmonary interstitial edema.
  • The condition was linked to the surgical event, highlighting a potential risk factor.

Implications:

  • This case underscores the importance of considering NPPE in postoperative patients presenting with respiratory distress.
  • Early diagnosis and intervention can prevent severe outcomes and improve patient prognosis.
  • Awareness of NPPE triggers, including surgical airway manipulation, is vital for anesthesiologists and surgeons.