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Related Concept Videos

Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

7.0K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
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Three-Compartment Open Model01:06

Three-Compartment Open Model

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The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
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Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

3.0K
The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
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Two-Compartment Open Model: Overview01:05

Two-Compartment Open Model: Overview

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Multicompartmental models are crucial tools in pharmacokinetics, providing a framework to understand how drugs move within the body. The two-compartment model is a crucial subtype, segmenting the body into central and peripheral compartments. The central compartment represents areas with high blood flow, such as plasma and highly perfused organs like the kidneys and liver, while the peripheral compartment signifies tissues with lower blood flow, like adipose tissue and muscle tissue.
The...
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Fluid Movement Between Compartments01:18

Fluid Movement Between Compartments

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The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
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One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

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Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
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Related Experiment Video

Updated: Jan 21, 2026

Preparation and Maintenance of Dorsal Root Ganglia Neurons in Compartmented Cultures
07:43

Preparation and Maintenance of Dorsal Root Ganglia Neurons in Compartmented Cultures

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Compartments in the Ring.

Tomoko Nishiyama1

  • 1Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.

Molecular Cell
|July 27, 2019
PubMed
Summary
This summary is machine-generated.

Sister chromatid cohesion involves the cohesin ring trapping DNA. New research reveals this ring has two sub-compartments, changing our understanding of DNA entrapment by chromosomal organizers.

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Related Experiment Videos

Last Updated: Jan 21, 2026

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Sister chromatid cohesion is crucial for accurate chromosome segregation during cell division.
  • The cohesin complex, a ring-shaped protein structure, has been the primary model for mediating this cohesion through DNA entrapment.

Purpose of the Study:

  • To investigate the structural organization of the cohesin ring.
  • To elucidate the mechanism by which cohesin entraps DNA for sister chromatid cohesion.

Main Methods:

  • Utilized advanced imaging and biochemical techniques to analyze cohesin complex structure.
  • Performed experiments to assess DNA binding and release dynamics in relation to cohesin conformation.

Main Results:

  • Demonstrated that the cohesin ring is not a single entity but is divided into two distinct sub-compartments.
  • Provided evidence that these sub-compartments play a critical role in the dynamic entrapment and release of DNA.

Conclusions:

  • The established model of cohesin function needs revision based on its newly identified two-compartment structure.
  • This structural insight offers a refined understanding of sister chromatid cohesion and DNA management by chromosomal organizers.