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Ozone Inhibits APP/Aβ Production and Improves Cognition in an APP/PS1 Transgenic Mouse Model.
Si-Yu Lin1, Jun Ma1, Jian-Xiong An1
1Department of Anesthesiology, Pain Medicine & Critical Care Medicine, Aviation General Hospital of China Medical University & Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beiyuan Rd 3#, Beijing, 100012, China.
Neuroscience
|July 27, 2019
Summary
Ozone therapy may offer a new treatment for Alzheimer's disease (AD). Studies show ozone injections improved memory and reduced key Alzheimer's disease markers in mice.
Area of Science:
- Neuroscience
- Pharmacology
- Gerontology
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder with no effective treatments.
- Amyloid-beta (Aβ) peptide production and deposition are central to AD pathology.
- Investigating novel therapeutic interventions for AD is crucial.
Purpose of the Study:
- To investigate the therapeutic potential of ozone intraperitoneal injection in an Alzheimer's disease mouse model.
- To evaluate the effects of ozone on cognitive function and AD-related neuropathology.
Main Methods:
- APP/PS1 transgenic mice received daily intraperitoneal injections of ozone (30 or 50 μg/ml) or abdominocentesis for 25 days.
- Cognitive function was assessed using the Morris water maze and open field test.
- Levels of amyloid-beta precursor protein (APP) and other AD biomarkers were measured via ELISA, Western blot, and immunohistochemistry.
Main Results:
- Ozone treatment significantly ameliorated behavioral deficits in APP/PS1 mice, improving spatial learning-memory and reducing anxiety.
- Ozone administration led to a reduction in amyloid-beta precursor protein (APP) levels in the prefrontal cortex and hippocampus.
- Pathological deterioration associated with Alzheimer's disease was alleviated by ozone treatment.
Conclusions:
- Ozone intraperitoneal injection demonstrates therapeutic potential for Alzheimer's disease.
- Ozone therapy may mitigate cognitive decline and reduce key pathological hallmarks of AD.
- Further research into ozone administration as an AD treatment is warranted.
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