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Electrospun Fibrous Scaffolds of Polyglycerol-dodecanedioate for Engineering Neural Tissues From Mouse Embryonic Stem Cells
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Electrospun biodegradable chitosan based-poly(urethane urea) scaffolds for soft tissue engineering.

Tânia Vieira1, Jorge Carvalho Silva2, A M Botelho do Rego3

  • 1Centro de Investigação de Materiais, Institute for Nanostructures, Nanomodelling and Nanofabrication, CENIMAT-I3N, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.

Materials Science & Engineering. C, Materials for Biological Applications
|July 28, 2019
PubMed
Summary

Biodegradable polyurethanes (PUs) were electrospun into fibrous scaffolds. Chitosan-based PUs enhanced cell adhesion and proliferation, suggesting potential for tissue engineering.

Keywords:
Biodegradable polyurethanesCell adhesion and proliferationChitosanElectrospinningSoft tissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Scaffold properties critically influence tissue regeneration.
  • Biodegradable polymers are essential for temporary tissue support.
  • Electrospinning offers versatile scaffold fabrication.

Purpose of the Study:

  • To synthesize and characterize biodegradable polyurethanes (PUs) for tissue engineering scaffolds.
  • To investigate the effect of chitosan (CS) incorporation on PU properties.
  • To evaluate the biocompatibility and cell interaction of electrospun PU scaffolds.

Main Methods:

  • Polyurethanes synthesized using polycaprolactone-diol, chitosan, and/or dimethylol propionic acid.
  • Electrospinning technique used to create fibrous scaffolds.
  • Material characterization via FTIR, NMR, SEM, tensile testing, XRD, contact angle measurements, and XPS.
  • In vitro biocompatibility assessed using human dermal fibroblasts.

Main Results:

  • Electrospun PU fibers with diameters around 1 μm were successfully fabricated.
  • Chitosan content increased Young's modulus; films exhibited higher modulus than fiber mats.
  • Chitosan-based PUs showed improved recovery, resilience, wettability, and surface chemistry favoring cell interaction.
  • Cells adhered better to fiber mats, and proliferation was observed on chitosan-containing PUs.

Conclusions:

  • Electrospun chitosan-based polyurethanes demonstrate promising characteristics for soft tissue engineering scaffolds.
  • The developed fibrous structures support cell adhesion and proliferation.
  • These materials offer a viable alternative for regenerative medicine applications.