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Updated: Jan 21, 2026

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Graphene oxide as a polymeric N-halamine carrier and release platform: Highly-efficient, sustained-release
Nengyu Pan1, Yingfeng Wang1, Xuehong Ren1
1Key Laboratory of Eco-textiles of Ministry of Education, College of Textiles and Clothing, Jiangnan University, 214122, Jiangsu, China.
Abstract:
N-halamine compounds have been applied as antibacterial agents owing to the oxidative chlorine. In this work, graphene oxide (GO) as carrier was used to load N-halamine compounds for the sustained-release of chlorine in order to maintain long-term biocidal efficacies. 3‑(3'‑Acrylic acid propylester)‑5,5‑dimethylhydantoin (APDMH) was synthesized using 5,5‑dimethylhydantoin as a heterocyclic precursor and attached on the surface of GO nanosheets via in-situ polymerization. The modified GO composites were characterized by Fourier transform infrared (FT-IR) spectra, scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). The chlorinated GO nanosheets modified with polymerized APDMH (PAPDMH) were very stable and possessed long-term antibacterial properties. The GO-PAPDMH-Cl composites exhibited good antimicrobial efficacies against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli O157:H7) with log reductions of 7.20 and 7.06 within 30 min of contact time, respectively.
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