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Lipid Index Determination by Liquid Fluorescence Recovery in the Fungal Pathogen Ustilago Maydis
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Role of MCC/Eisosome in Fungal Lipid Homeostasis

Jakub Zahumensky1, Jan Malinsky2

  • 1Department of Microscopy, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic.

Biomolecules
|July 28, 2019
PubMed

Insights

The fungal membrane compartment of Can1 (MCC/eisosome) is an ergosterol-rich domain regulating cellular processes. This review highlights its role in lipid metabolism, emphasizing plasma membrane regulation of cellular functions.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The membrane compartment of Can1 (MCC/eisosome) is a well-characterized fungal plasma membrane microdomain.
  • It is an ergosterol-rich domain stabilized by the eisosome, a protein complex of Pil1 and Lsp1.
  • These proteins bind phosphatidylinositol 4,5-bisphosphate, shaping the microdomain with curved edges.

Purpose of the Study:

  • To review the proposed role of the MCC/eisosome in regulating lipid metabolism.
  • To explore the MCC/eisosome's function as a regulator of diverse cellular processes.
  • To discuss the significance of plasma membrane-based regulation of intracellular events.

Main Methods:

  • Literature review of studies on fungal membrane microdomains.
  • Analysis of protein-lipid interactions within the MCC/eisosome.
  • Investigation of dynamic protein localization in response to cellular conditions.

Main Results:

  • The MCC/eisosome exhibits distinct morphology and lipid composition.
  • It dynamically regulates protein localization based on cellular conditions like lipid balance and nutrient availability.
  • The MCC/eisosome influences metabolic pathways, morphogenesis, signaling, and mRNA decay.

Conclusions:

  • The MCC/eisosome is a versatile regulator of cellular processes, including lipid metabolism.
  • Its function highlights the plasma membrane's role in sensing and responding to environmental cues.
  • Further research is needed to fully elucidate the molecular mechanisms governing MCC/eisosome function.
Keywords:
MCCeisosomeergosterollipidsmicrodomainphosphoinositidesregulationsphingolipids

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