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Macroenvironment-gene-microenvironment interactions in ultraviolet radiation-induced melanomagenesis
Xuan Mo1, Sarah Preston1, M Raza Zaidi1
1Fels Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, United States.
Advances in Cancer Research
|July 28, 2019
Summary
Ultraviolet radiation (UVR) is a primary cause of melanoma, the deadliest skin cancer. This review explores how UVR interacts with genetic factors to promote melanoma development.
Area of Science:
- Oncology
- Dermatology
- Environmental Health
Background:
- Cutaneous malignant melanoma incidence is rising globally.
- Ultraviolet radiation (UVR) is the primary environmental risk factor for melanoma.
- Molecular mechanisms linking UVR exposure to melanoma are not fully understood.
Purpose of the Study:
- To provide an overview of UVR's effects on skin.
- To explore the interplay between environmental factors and genetic predisposition in melanoma.
- To elucidate the complex mechanisms driving melanoma development.
Main Methods:
- Review of epidemiological data on melanoma.
- Analysis of molecular mechanisms of UVR-induced skin damage.
- Integration of genetic and environmental factors in melanomagenesis.
Main Results:
- UVR significantly impacts the skin's microenvironment.
- Genetic factors play a crucial role alongside UVR exposure.
- Melanoma arises from a complex interaction between intrinsic and extrinsic factors.
Conclusions:
- Understanding the interplay of UVR and genetics is key to combating melanoma.
- Further research into molecular pathways is needed.
- This overview synthesizes current knowledge on UVR-driven melanoma.
Keywords:
AKTBRAFCDKN2ACPDDNA repairEumelaninGeneticsGenomicsImmunosuppressionInflammationKeratinocyteMAPK pathwayMC1RMelaninMelanocyteMelanomaMetastasisMicroenvironmentMouse modelsMutagenesisMutationsNRASPTENPheomelaninPigmentationPreventionProgressionReceptor tyrosine kinaseSignature mutationsSkinSunscreenUVUVAUVBUVCUltraviolet radiationVitamin DWNT
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