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Updated: Jan 21, 2026

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

An expanded landscape of human long noncoding RNA.

Shuai Jiang¹, Si-Jin Cheng¹, Li-Chen Ren¹

¹Biomedical Pioneering Innovation Center (BIOPIC), Beijing Advanced Innovation Center for Genomics (ICG), Center for Bioinformatics (CBI), and State Key Laboratory of Protein and Plant Gene Research at School of Life Sciences, Peking University, Beijing 100871, China.

Nucleic Acids Research

|July 28, 2019

Summary

This study presents RefLnc, a comprehensive human long noncoding RNA (lncRNA) atlas from 14,166 samples. It identifies novel lncRNAs linked to biological factors and cancer patient outcomes.

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Area of Science:

Genomics
Molecular Biology
Bioinformatics

Background:

Long noncoding RNAs (lncRNAs) play crucial roles in biological processes and diseases.
Understanding the full spectrum of lncRNAs is essential for biological and medical research.

Purpose of the Study:

To create an expanded, high-quality human lncRNA atlas named RefLnc.
To identify novel lncRNAs associated with demographic factors and cancer progression.

Main Methods:

Analysis of a large compendium of 14,166 normal and tumor tissue samples.
Comprehensive annotation of lncRNAs using multiple data sources.
Development of a user-friendly online portal for data access.

Main Results:

Identification of 275 novel intergenic lncRNAs correlated with sex, age, or race.
Discovery of 369 novel lncRNAs associated with patient survival, clinical stage, metastasis, or recurrence.
Creation of RefLnc, an expanded catalog of human lncRNAs.

Conclusions:

RefLnc significantly enhances the landscape of known human lncRNAs.
The identified novel lncRNAs offer potential biomarkers for cancer and insights into human biology.
The RefLnc portal serves as a valuable resource for lncRNA research in health and disease.