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Related Experiment Video

Updated: Jan 21, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Challenges With Left Ventricular Functional Parameters: The Pediatric Heart Network Normal Echocardiogram Database.

Peter C Frommelt¹, L LuAnn Minich², Felicia L Trachtenberg³

¹Medical College of Wisconsin, Milwaukee, Wisconsin.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography

|July 29, 2019

Summary

This summary is machine-generated.

Reliable left ventricular (LV) size measurements in children are achievable, but calculated systolic function indices like shortening fraction (SF) and ejection fraction (EF) show significant interobserver variability. This variability is more pronounced in younger, smaller children.

Keywords:

Echocardiography Ejection fraction Left ventricle Pediatric Shortening fraction

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Last Updated: Jan 21, 2026

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Published on: April 8, 2013

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Published on: October 28, 2020

Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Published on: May 24, 2021

Area of Science:

Pediatric Cardiology
Echocardiography
Cardiac Imaging

Background:

Assessing left ventricular (LV) systolic function reliability in children using echocardiography is crucial.
Previous studies have not extensively evaluated interobserver variability in LV size and function indices in a large pediatric cohort.

Purpose of the Study:

To estimate interobserver variability in standard measurements of LV size and systolic function in healthy children.
To assess the reliability of calculated LV systolic functional indices derived from blinded echocardiographic measurements.

Main Methods:

Utilized the Pediatric Heart Network Normal Echocardiogram Database of healthy children (≤18 years).
Two independent expert pediatric echocardiographic observers remeasured LV dimensions on a subset of studies, blinded to calculated volumes and indices.
Calculated LV volumes and systolic functional indices (shortening fraction [SF] and ejection fraction [EF]) were compared between core lab and independent observers.

Main Results:

High reproducibility was observed for individual LV size parameters (intraclass correlation coefficients: 0.81-0.99).
Lower reproducibility was found for SF (0.24) and EF (0.56).
A significant proportion of subjects with normal or abnormal SF/EF values based on core lab measurements were classified differently by independent observers, indicating variability in functional index assessment.

Conclusions:

Blinded measurements of LV size demonstrate good reproducibility in healthy children.
Calculated LV functional indices (SF/EF) exhibit significant interobserver variability despite normal systolic function.
Abnormal LV functional indices were more prevalent in younger, smaller children, suggesting potential clinical implications for repeated measurements and subjective assessments.