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Hypertension in Children: Narrative Review of Epidemiology, Outcome and Target Organ Damage
1Division of Pediatric Cardiology, Department of Pediatrics, Kravis Children's Hospital, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Insights
Pediatric hypertension, affecting 4% of children, is a major risk factor for cardiovascular disease. Early diagnosis and treatment are crucial for managing blood pressure and preventing long-term heart issues.
Area of Science:
- Pediatric Cardiology
- Public Health
- Epidemiology
Background:
- Hypertension is the primary risk factor for cardiovascular disease globally.
- Pediatric hypertension affects approximately 4% of children, often clustering with other health disparities.
- Elevated blood pressure in childhood can track into adulthood, increasing the risk of premature heart disease.
Purpose of the Study:
- To review the epidemiology of pediatric hypertension.
- To examine the association between pediatric hypertension and cardiovascular outcomes.
- To synthesize current knowledge on prevalence, blood pressure tracking, and sequelae.
Main Methods:
- A narrative review of studies.
- PubMed/MEDLINE database search conducted for studies published between 1997 and April 2026.
- Focused on epidemiology, blood pressure tracking, and cardiovascular sequelae.
Main Results:
- Pediatric hypertension is linked to increased cardiovascular disease risk.
- Blood pressure tracking from childhood to adulthood is evident.
- Ambulatory blood pressure monitoring and echocardiography are key diagnostic tools.
Conclusions:
- Early identification and management of pediatric hypertension are essential.
- While intermediate outcomes show improvement with treatment, further research is needed for hard cardiovascular outcomes.
- Understanding the epidemiology and long-term effects is critical for public health strategies.
Abstract:
Hypertension is the leading risk factor for cardiovascular disease. Epidemiologic studies have demonstrated that pediatric hypertension may increase the risk of premature heart disease. Pediatric hypertension affects about 4% of children and clusters with other risk factors and social disparities in health. In addition to observed target organ damage, there is evidence for tracking blood pressure from childhood to adulthood. Ambulatory blood pressure monitoring is the recommended method for diagnosis, and echocardiography is used to assess target organ damage. A diagnostic workup in children depends on the age at presentation, severity of hypertension, diurnal pattern, evidence of target organ damage, and response to treatment. Treatment follows a similar framework to adult hypertension and studies demonstrate improvement in intermediate outcomes with treatment. However, further studies are needed to establish benefit in hard outcomes. This review focuses on studies evaluating the epidemiology of pediatric hypertension and its association with cardiovascular outcomes. Relevant domains included prevalence, blood pressure tracking, and cardiovascular sequelae. To compile data for this narrative review, a PubMed/MEDLINE database search was performed for studies published between 1997 and April 2026.
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