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Updated: Jan 21, 2026

Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons
Published on: January 7, 2019
A special association between Charcot-Marie-Tooth type 1A disease and relapsing remitting multiple sclerosis
Yahya Doğan1, Şule Gül1, Ahmet Cevdet Ceylan2
1Hacettepe University Medical School, Department of Physical and Rehabilitation Medicine, Ankara, Turkey.
Background:
Central nervous system involvement has been reported in different subtypes of Charcot-Marie-Tooth (CMT) diseases. The increasing number of cases with CMT and MS may provide further information about the common pathway of demyelination and MS pathogenesis.
Case Presentation:
We report the case of a 21-year-old woman with CMT1A and MS. Bilateral rest and intention tremor, steroid associated psychotic episodes, and severe disability at an early age were unexpected aspects of this case.
Conclusion:
PMP22, the target protein in CMT1A, shares partial homology with other CNS proteins. PMP22 gene might be relevant to a common pathway of the demyelinating process.
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