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Updated: Jan 21, 2026

Extraction, Labeling, and Purification of Lineage-Specific Cells from Human Antral Follicles
Published on: November 30, 2022
Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity
Jason H Kurzer1, Olga K Weinberg2
1Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Room 1401K, Stanford, CA 94305, USA.
Abstract:
Acute leukemias of ambiguous lineage (ALAL) include acute undifferentiated leukemia and mixed-phenotype acute leukemia (MPAL). This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment criteria for blasts harboring more than one lineage-associated marker. In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lymphoblastic leukemia. Finally, the prognosis and current treatments of MPAL are briefly discussed.
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