Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

11.4K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.4K
Gene Regulation During Sporulation01:17

Gene Regulation During Sporulation

456
Sporulation is a complex developmental process that allows certain Gram-positive bacteria, such as Bacillus subtilis and Clostridium species, to survive extreme environmental conditions. This process is tightly regulated by a series of signaling cascades and transcriptional controls, ensuring the formation of a highly resistant endospore.Sporulation is triggered by unfavorable conditions, such as nutrient depletion, and is governed by a phosphorelay system. One of the sensor kinases, such as...
456
Repressed Memory01:16

Repressed Memory

504
Repressed memories are a psychological phenomenon where memories of traumatic events are unconsciously blocked from a person's awareness. This process occurs as a defense mechanism, protecting the mind from the emotional impact of distressing or painful experiences. For example, a person who has experienced childhood trauma may grow up with no conscious recollection of the event. In such cases, the memories are thought to be buried deep within the subconscious, inaccessible to the conscious...
504
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

8.7K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
8.7K
Master Transcription Regulators02:23

Master Transcription Regulators

7.7K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.7K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.5K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CRISPR-Cas-Based Platform for Single-Step Quantification of Monoclonal Antibodies at Point-of-Care.

ACS sensors·2026
Same author

A digital archive reveals how a funding agency cooperated with academics to support the nascent field of genomics.

Nature communications·2026
Same author

Association of neurogenic orthostatic hypotension with cognitive decline in Parkinson's disease: a longitudinal cohort study.

Frontiers in neurology·2026
Same author

Variable deep learning training horizons reveal the temporal complexity of biological systems.

microPublication biology·2026
Same author

Synthetic DNA Transducers Integrate DNA Repair to CRISPR Signal Transduction.

ACS sensors·2026
Same author

Perioperative clinical outcomes of remimazolam in regional anesthesia: a systematic review of sedation and safety parameters.

BMC anesthesiology·2026

Related Experiment Video

Updated: Jan 21, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.9K

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism.

Justin J Cassidy1, Sebastian M Bernasek2, Rachael Bakker3

  • 1Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.

Cell
|July 30, 2019
PubMed
Summary

Metabolic changes impact animal development timing. Layered gene repression helps synchronize development with metabolism, reducing errors and potentially shortening reproductive cycles.

Keywords:
Drosophilacontrol theorydevelopmentmathematical modelingmetabolismmicroRNA

More Related Videos

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.3K
Multimodal Optical Imaging Platform for Studying Cellular Metabolism
04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

1.0K

Related Experiment Videos

Last Updated: Jan 21, 2026

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

6.9K
Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

28.3K
Multimodal Optical Imaging Platform for Studying Cellular Metabolism
04:47

Multimodal Optical Imaging Platform for Studying Cellular Metabolism

Published on: June 6, 2025

1.0K

Area of Science:

  • Developmental biology
  • Systems biology
  • Genetics

Background:

  • Metabolic conditions significantly influence the pace of animal development.
  • Developmental gene regulatory networks (GRNs) must adapt to variable timescales imposed by metabolism.

Purpose of the Study:

  • To investigate how layered repression mechanisms in gene regulatory networks (GRNs) synchronize with metabolic fluctuations.
  • To understand how reducing metabolic rates affects developmental errors in the presence of altered gene repression.

Main Methods:

  • Experimental manipulation of repressors (transcription, mRNA, protein stability, microRNAs) in Drosophila.
  • Utilizing a mathematical model to simulate GRN dynamics under varying metabolic conditions.
  • Measuring developmental error rates and gene expression dynamics.

Main Results:

  • Loss of repressors led to fewer developmental errors when metabolism was lowered.
  • Eliminating microRNA repressors partially rescued development to maturity under reduced metabolism.
  • Mathematical modeling indicated that lower metabolism suppresses developmental errors by limiting auxiliary repressor influence.
  • Experimental data showed gene expression dynamics were less impacted by repressor loss at reduced metabolism.

Conclusions:

  • Layered repression provides robustness to developmental gene regulatory networks by suppressing errors.
  • Reduced metabolism can mitigate developmental errors caused by repressor deficiencies.
  • This mechanism may offer an evolutionary pathway for achieving shorter reproductive cycles.