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Related Concept Videos

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Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars. 
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Related Experiment Video

Updated: Jan 21, 2026

A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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White matter mean diffusivity correlates with myelination in tuberous sclerosis complex.

Jurriaan M Peters1,2, Robbert R Struyven2, Anna K Prohl2

  • 1Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Annals of Clinical and Translational Neurology
|July 30, 2019
PubMed
Summary

Diffusion tensor imaging (DTI) in tuberous sclerosis complex (TSC) reveals white matter abnormalities linked to myelination. This study correlates DTI metrics with histopathology, clarifying diffusion changes in TSC.

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Area of Science:

  • Neuroimaging
  • Neuropathology
  • Biomarkers

Background:

  • Diffusion tensor imaging (DTI) is a key biomarker for neurological disease in tuberous sclerosis complex (TSC).
  • Understanding the histopathological basis of abnormal DTI findings in TSC is crucial for disease characterization.

Purpose of the Study:

  • To correlate high-resolution ex vivo DTI with histopathology in various TSC tissue types.
  • To elucidate the microscopic origins of altered white matter diffusion in TSC.

Main Methods:

  • High-resolution DTI and structural MRI were performed on surgical TSC specimens.
  • Histopathological staining for myelin (LFB), gliosis (GFAP), and neurons (NeuN) was conducted.
  • Colocalization analysis and linear mixed-effects modeling were used to correlate imaging and pathology.

Main Results:

  • White matter and perituber myelination (LFB) correlated with fractional anisotropy (FA) and inversely with mean diffusivity (MD).
  • White matter gliosis (GFAP) correlated with MD and inversely with FA.
  • Neuronal density correlated with MD; white matter MD showed the strongest correlation with myelination.

Conclusions:

  • DTI abnormalities in TSC tissues correspond to specific histopathological features.
  • White matter diffusivity in TSC is significantly correlated with myelination levels.