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Updated: Jan 21, 2026

Quantification of Violacein in Chromobacterium violaceum and Its Inhibition by Bioactive Compounds
Published on: August 8, 2025
Highly branched poly(N-isopropyl acrylamide) functionalized with an inducer molecule suppresses quorum sensing in
Joanna Shepherd1, Thomas Swift, Chien-Yi Chang
1School of Clinical Dentistry, University of Sheffield, Sheffield, S10 2TA, UK. j.shepherd@sheffield.ac.uk.
Abstract:
Bacterial quorum sensing has been implicated in a number of pathogenic bacterial processes, such as biofilm formation, making it a crucial target for developing materials with a novel antibiotic mode of action. This paper describes poly(N-isopropyl acrylamide) that has been covalently linked, at multiple chain ends, to homoserine lactone to give a highly branched polymer functionalized with a key messenger molecule implicated in QS. This novel functional material has shown promising anti-QS activity in a Chromobacterium violaceum assay.
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