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Updated: Jan 21, 2026

Analysis and Specification of Starch Granule Size Distributions
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[Quality evaluation of Moutan Cortex Formula Granules].

Xin-Gang DU1, Hui-Jie Jiang2, Hui Zhang2

  • 1National Resource Center of Chinese Materia Medica,China Academy of Chinese Medical Sciences Beijing 100700,China Center for Post-doctoral Research,China Academy of Chinese Medical Sciences Beijing 100700,China Anhui Jiuzhou Fangyuan Pharmaceutical Co.,Ltd. Bozhou 236800,China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|July 30, 2019
PubMed
Summary

A quality evaluation system for Moutan Cortex Formula Granules was developed using HPLC, characteristic chromatograms, and mass spectrometry. This system ensures consistent quality and aids in process control for this traditional herbal medicine.

Keywords:
Formula GranulesMoutan Cortexcharacteristic chromatogramcontent determinationmass spectrometrypaeoniflorinpaeonol

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Area of Science:

  • Pharmacognosy
  • Analytical Chemistry
  • Traditional Chinese Medicine

Background:

  • Moutan Cortex Formula Granules are a traditional herbal medicine requiring robust quality control.
  • Standardized evaluation methods are crucial for ensuring the safety and efficacy of herbal formulations.

Purpose of the Study:

  • To establish a comprehensive quality evaluation system for Moutan Cortex Formula Granules.
  • To ensure the consistency and reliability of Moutan Cortex Formula Granules through advanced analytical techniques.

Main Methods:

  • High-performance liquid chromatography (HPLC) for quantitative analysis of key compounds.
  • Characteristic chromatogram method for qualitative identification and fingerprinting.
  • Mass spectrometry (MS) for comprehensive compound identification.

Main Results:

  • Established HPLC methods determined average contents of paeoniflorin (1.72%) and paeonol (1.42%).
  • Characteristic chromatograms identified 7 key peaks, providing a fingerprint for Moutan Cortex Formula Granules.
  • Mass spectrometry identified a total of 40 compounds, including gallic acids, paeoniflorins, paeonols, flavonoids, and benzoic acids.

Conclusions:

  • The developed multi-analytical method system provides a scientific basis for quality evaluation of Moutan Cortex Formula Granules.
  • This system is vital for enhancing quality control and ensuring the therapeutic consistency of the herbal product.