A Core Outcome Set for Critical Care Ventilation Trials.

Area of Science:

• Critical Care Medicine
• Clinical Trials Methodology
• Respiratory Therapy

Background:

• Standardized outcome measures are crucial for clinical trials evaluating interventions to modify mechanical ventilation duration.
• Current research lacks a consensus on core outcomes, hindering comparability and methodological rigor.

Framework:

• A two-stage international consensus process was employed, involving a Delphi study and consensus meetings.
• The process engaged diverse stakeholders, including patients, healthcare professionals, and industry representatives.

Implementation:

• 222 participants from 38 organizations across 27 countries contributed to the consensus process.
• A rigorous Delphi study and subsequent consensus meetings identified six core outcomes: extubation, reintubation, duration of mechanical ventilation, length of stay, health-related quality of life, and mortality.

Implications:

• The developed core outcome set provides a standardized framework for future clinical trials in mechanical ventilation.
• This standardization will enhance the methodological quality and comparability of research, ultimately improving patient care.