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Updated: Jan 21, 2026

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
Published on: January 27, 2023
Reliability of noninvasive hemodynamic assessment with Doppler echocardiography: comparison with the invasive
Marco de Scordilli1, Bruno Pinamonti2, Stefano Albani2
1Department of Medical Science, Surgery and Health (DCSMCS), University of Trieste, Ospedale di Cattinara.
Insights
Noninvasive echocardiography can reliably estimate many hemodynamic parameters. A multiparametric approach is recommended for left ventricle filling pressures, proving effective even in patients with pulmonary hypertension.
Area of Science:
- Cardiology
- Medical Imaging
- Hemodynamics
Background:
- Right heart catheterization (RHC) is invasive.
- Accurate hemodynamic assessment is crucial for patient management.
- Noninvasive echocardiography offers a potential alternative for hemodynamic evaluation.
Purpose of the Study:
- To assess the reliability and reproducibility of noninvasive echocardiographic techniques.
- To compare echocardiographic estimations with invasive RHC measurements.
- To evaluate the clinical utility of echocardiography for hemodynamic parameters.
Main Methods:
- 84 patients undergoing RHC had transthoracic echocardiography.
- Key hemodynamic parameters were measured noninvasively.
- Bland-Altman analysis compared invasive and noninvasive data.
Main Results:
- Echocardiography showed moderate correlation for right atrial pressure.
- Pulmonary artery pressure (PAP) estimation demonstrated good correlation and feasibility.
- Left ventricle filling pressure assessment using a multiparametric approach showed good correlation.
- Noninvasive pulmonary vascular resistance and cardiac output lacked clinical accuracy.
Conclusions:
- Noninvasive echocardiography can adequately estimate several hemodynamic parameters.
- A multiparametric approach is advised for left ventricle filling pressures.
- Current echocardiographic guidelines are reliable in diverse populations, including those with pulmonary hypertension.
Aims:
The study aimed at evaluating the reliability and reproducibility of various noninvasive echocardiographic techniques for the estimation of the main hemodynamic parameters in clinical practice.
Methods:
A total of 84 patients with a generic indication of right heart catheterization (RHC) executed a transthoracic echocardiography shortly before or after the RHC. All the parameters necessary for a noninvasive hemodynamic evaluation of right atrial pressure, pulmonary artery pressure (PAP), pulmonary capillary wedge pressure, pulmonary vascular resistance and cardiac output were acquired and the agreement with the invasive measures was evaluated by a Bland-Altman analysis.
Results:
Noninvasive evaluation of right atrial pressure showed a moderate and low correlation with RHC using inferior vena cava parameters (r = 0.517) and tricuspid E/E' ratio (sensitivity 0.23, specificity 0.72), respectively. PAPs estimation from the tricuspid regurgitation peak velocity had a good correlation (r = 0.836) and feasibility (82.1%), as well as PAPm from tricuspid regurgitation mean gradient (r = 0.78, applicability 72.6%) and from pulmonary acceleration time (sensitivity 0.85, specificity 0.5, applicability 92.9%). Pulmonary capillary wedge pressure multiparametric evaluation, as suggested by the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging recommendations, showed a good correlation (sensitivity 0.96, specificity 0.59). The noninvasive evaluation of pulmonary vascular resistance and cardiac output did not prove to be clinically accurate.
Conclusion:
Various hemodynamic parameters can be adequately estimated with noninvasive methods. In particular, a multiparametric approach for the evaluation of left ventricle filling pressures is advisable and the 2016 American Society of Echocardiography/European Association of Cardiovascular Imaging recommendations are reliable even in a heterogeneous population with a significant quota of precapillary pulmonary hypertension.
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