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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
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A flexible-imprinted capacitive sensor for rapid detection of adrenaline
Dhanjai1, Nancy Yu2, Samuel M Mugo2
1Physical Sciences Department, MacEwan University, 10700-104 Avenue, Edmonton, AB, T5J 4S2, Canada; Department of Mathematical and Physical Sciences, Concordia University of Edmonton, 7128 Ada Blvd NW, Edmonton, AB, T5B 4E4, Canada.
Talanta
|July 31, 2019
Summary
This study presents an inexpensive, non-enzymatic biosensor for detecting adrenaline. The novel capacitive sensor utilizes layer-by-layer assembly for sensitive and selective adrenaline measurements in biological samples.
Area of Science:
- Biomedical Engineering
- Materials Science
- Analytical Chemistry
Background:
- Adrenaline (epinephrine) is a crucial neurotransmitter and hormone.
- Accurate and sensitive detection methods for adrenaline are vital for biological and medical research.
- Existing detection methods may be costly, complex, or lack selectivity.
Purpose of the Study:
- To develop an inexpensive, non-enzymatic capacitive biosensor for adrenaline detection.
- To demonstrate the sensor's sensitivity, selectivity, and reproducibility.
- To validate the sensor's performance using real biological samples.
Main Methods:
- Fabrication of a layer-by-layer (LbL) assembly sensor using polydimethylsiloxane (PDMS), carbon nanotube-cellulose nanocrystals (CNC/CNT), and adrenaline-imprinted poly(aniline/phenylboronic acid) (pANI/PBA).
- Capacitive detection of adrenaline in standard solutions and zebra fish brain samples.
- Characterization of sensor performance, including linearity, detection limit, selectivity, and reproducibility.
Main Results:
- The sensor exhibited a linear response from 0.001 to 100 μM with a low detection limit (LOD) of 0.001 μM.
- High sensitivity and selectivity for adrenaline detection were demonstrated.
- The sensor showed good reproducibility (15.7%) and precision (0.5-5.0%) in detecting adrenaline in zebra fish brain samples.
Conclusions:
- The developed LbL-assembled capacitive sensor offers a cost-effective and efficient method for adrenaline detection.
- The sensor's performance in real biological samples suggests its potential for near real-time monitoring.
- This biosensor is suitable for practical applications in detecting adrenaline in biological fluids with minimal sample consumption.
Keywords:
Adrenaline imprinted sensorBiomimetic flexible sensorsCapacitive sensorsMolecular imprinting polymer (MIP)More Related Videos
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