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Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
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DNA replication has three main steps: initiation, elongation, and termination. Replication in prokaryotes begins when initiator proteins bind to the single origin of replication (ori) on the cell's circular chromosome. Replication then proceeds around the entire circle of the chromosome in each direction from the two replication forks, resulting in two DNA molecules.
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Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique
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Publisher Correction: A visual tool for defining reproducibility and replicability.

Prasad Patil1,2, Roger D Peng3, Jeffrey T Leek4

  • 1Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Nature Human Behaviour
|July 31, 2019
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This summary is machine-generated.

This study has been amended. Please refer to the updated version for the most current findings and analysis.

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Area of Science:

  • This research falls within the scope of scientific publication ethics and scholarly communication.

Context:

  • A published paper has undergone an amendment.
  • This amendment is accessible through a direct link provided at the beginning of the document.

Purpose:

  • To inform readers about a necessary correction or update to the original publication.
  • To ensure readers access the most accurate and current version of the research.

Summary:

  • An amendment has been issued for this scientific paper.
  • The revised version is readily available via a link at the top of the original paper.

Impact:

  • Ensures the integrity of the scientific record.
  • Facilitates accurate dissemination of research findings to the scientific community.