Related Experiment Video
Updated: Sep 19, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A research agenda for making evidence useful, usable and used in policymaking
Max Spohn1, Amira Boland2, Jessica Lasky-Fink1
1Harvard Kennedy School, Harvard University, Cambridge, MA, USA.
Abstract:
Despite growing investments in evidence-based policymaking, a substantial gap remains between the production of policy-relevant research and the use of evidence to impact policy. This Perspective argues that overcoming this production-adoption gap requires reconceptualizing evidence adoption as a series of behavioural and organizational hurdles that determine whether evidence is useful, usable and, ultimately, used. Drawing on a large interdisciplinary literature, we develop a unified framework and highlight key gaps in our understanding of each of these critical stages for bringing evidence to scale. We conclude by outlining a research agenda for advancing our understanding of why a production-adoption gap persists and knowledge of what works to increase evidence adoption-which, together, are essential for ensuring that the evidence-based policymaking movement meets its promise of improving societal outcomes.
Related Concept Videos
The Scientific Method in Nursing Process
When using research findings to change practice, one must understand the process used to guide a study. The scientific method is a systematic, step-by-step process that supports the data's validity, reliability, and generalizability. As a result, findings can be safely...
Archival Research
Bias in Epidemiological Studies
Scientific Nature of Social Psychology
Introduction to Epidemiology
Strategies for Assessing and Addressing Confounding
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
