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Related Concept Videos

Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

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Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

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Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
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Prescription Drug Monitoring Program Reminder Emails, Program Use, and Prescribing: A Randomized Clinical Trial.

Adam Sacarny1,2,3, Tatyana Avilova4, Ian Williamson5

  • 1Department of Health Policy and Management, Mailman School of Public Health, Columbia University, New York, New York.

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|February 3, 2026
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Summary
This summary is machine-generated.

Email campaigns effectively increased clinician engagement with Prescription Drug Monitoring Programs (PDMPs), especially those highlighting legal requirements. While PDMP use rose, guideline-discordant opioid prescribing did not significantly change.

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Area of Science:

  • Health Informatics
  • Public Health
  • Clinical Pharmacy

Background:

  • Prescription Drug Monitoring Programs (PDMPs) are crucial for safe opioid prescribing but face underutilization by clinicians.
  • Evidence regarding the effectiveness of digital outreach, such as email campaigns, to boost PDMP engagement is limited.

Purpose of the Study:

  • To determine if email communications can enhance clinician utilization of PDMPs.
  • To assess the subsequent impact of increased PDMP use on guideline-discordant opioid prescribing.

Main Methods:

  • A randomized clinical trial involving clinicians with suboptimal PDMP use in Minnesota.
  • Participants were randomized to receive emails emphasizing legal requirements, clinical benefits, or usual care.
  • PDMP engagement and guideline-discordant prescribing were measured within 60 days post-intervention.

Main Results:

  • Email campaigns significantly increased PDMP engagement compared to usual care.
  • Emails highlighting legal requirements led to a 26.5 percentage point increase in engagement.
  • Both email types improved account holding, database searches, and searches for high-risk patients, with effects lasting over 7 months.

Conclusions:

  • Email communications are a low-cost, scalable method to improve PDMP engagement among clinicians.
  • Interventions focusing on legal mandates appear most effective for driving PDMP use.
  • While not directly impacting prescribing patterns in this study, similar strategies could promote other clinical best practices.