Related Experiment Video
Updated: Jan 21, 2026

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
The Frailty Index in centenarians and their offspring
Beatrice Arosio1,2, E Ferri3, M Casati3
1Geriatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, University of Milan, Via Pace 9, 20122, Milan, Italy. beatrice.arosio@unimi.it.
The Frailty Index (FI) effectively measures biological aging. This study found significant differences in FI among centenarians, their offspring, and controls, confirming FI
Area of Science:
- Gerontology
- Biomarkers
- Aging Research
Background:
- Frailty is a key indicator of biological aging.
- The Frailty Index (FI) is a potential tool for assessing biological age.
Purpose of the Study:
- To design and validate the Frailty Index (FI) in a cohort of centenarians and their offspring.
- To compare FI values across centenarians, their offspring, and age-matched controls.
Main Methods:
- Development of the Frailty Index (FI).
- Recruitment of centenarians, their offspring, and sex- and age-matched controls.
- Statistical analysis of FI values and correlation with age.
Main Results:
- Mean FI was highest in centenarians (0.47), followed by controls (0.22), and offspring (0.15).
- Significant differences in FI were observed between offspring and controls (p=0.003).
- FI correlated significantly with age in offspring (r=0.46, p<0.001).
Conclusions:
- The Frailty Index (FI) serves as a reliable marker of biological age.
- FI can differentiate varying degrees of frailty, even in extremely old individuals.
- Offspring of centenarians exhibit lower frailty than controls, suggesting potential genetic or lifestyle influences.
Related Concept Videos
Altruism
What is a Species?
Genomic Imprinting and Inheritance
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
Speciation Rates
Imprinting
Types of Genetic Transfer Between Organisms

