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Photodynamic Surgery for Feline Injection-Site Sarcoma
Marina Martano1, Emanuela Morello1, Sofia Avnet2
1Department of Veterinary Sciences, University of Turin, 10095 Grugliasco, Italy.
Biomed Research International
|July 31, 2019
Summary
Photodynamic surgery and therapy (PDS/PDT) with acridine orange effectively prevented feline injection-site sarcoma recurrence in a case series. This approach improved local tumor control and survival rates, showing promise for human musculoskeletal sarcomas.
Area of Science:
- Oncology
- Veterinary Medicine
- Photodynamic Therapy
Background:
- Musculoskeletal sarcomas are aggressive human cancers with poor prognoses.
- Feline injection-site sarcoma (FISS) is a relevant animal model for human sarcomas.
- Current treatments for FISS often face challenges with complete tumor removal and recurrence.
Purpose of the Study:
- To evaluate the feasibility and efficacy of photodynamic surgery and therapy (PDS/PDT) using acridine orange in cats with FISS.
- To assess the potential of PDS/PDT to prevent tumor recurrence and improve outcomes.
- To establish a foundation for applying this technique to human musculoskeletal sarcomas.
Main Methods:
- A case series of cats with FISS were treated with PDS/PDT using acridine orange.
- Photodynamic surgery involved UV light activation of acridine orange to identify and excise residual tumor.
- Photodynamic therapy involved visible light activation of acridine orange for its cytocidal effect before wound closure.
Main Results:
- The PDS/PDT procedure was well-tolerated and easy to perform with no major complications.
- All treated cats achieved disease-free surgical margins.
- Treated cats showed no tumor recurrence and had significantly higher event-free survival rates compared to controls.
Conclusions:
- PDS and PDT with acridine orange are feasible and effective for managing FISS in cats.
- This combined approach significantly improves local tumor control and patient outcomes.
- The findings support further investigation of PDS/PDT with acridine orange for human musculoskeletal sarcomas.
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