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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
An efficient tandem synthesis of chromones from o-bromoaryl ynones and benzaldehyde oxime
Jing-Wen Zhang1, Wan-Wan Yang1, Lu-Lu Chen1
1Institute of Functional Organic Molecular Engineering, Henan Engineering Laboratory of Flame-Retardant and Functional Materials, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, China. wangyanbokf@henu.edu.cn danyunmeimei@qq.com.
Abstract:
An effective transition-metal-free strategy was developed for the preparation of chromones from o-bromoaryl ynones and benzaldehyde oxime through sequential C-O bond formation. This cyclization reaction could well tolerate a wide range of functional groups, and the corresponding chromones were given in moderate to excellent yields. Mechanistically, benzaldehyde oxime as a hydroxide source and 1,3-diketone derivatives as reaction intermediates were involved in this transformation.
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