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Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

Pseudoprogression: an indicator for cure in combined immunotherapy?

Lingdi Zhao¹, Yonghao Yang¹, Wei Li¹

¹Department of Immunotherapy, Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou City 450008, China.

|July 31, 2019

Summary

Complete remission was achieved in two metastatic renal clear cell cancer patients after pseudoprogression, using anti-PD-1 antibodies and cytokine-induced killer cells. This offers hope for previously untreatable cancers.

Keywords:

anti-PD-1 antitumor immune checkpoint inhibitors immunotherapy pseudoprogression

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Area of Science:

Immunotherapy
Oncology
Cancer Research

Background:

Pseudoprogression is an uncommon phenomenon in cancer treatment, typically indicating a favorable prognosis.
Complete remission following pseudoprogression has not been previously reported.
Metastatic renal clear cell cancer is often resistant to conventional therapies like multitargeted kinase inhibitors.

Observation:

Two patients with metastatic renal clear cell cancer experienced pseudoprogression after treatment failure with multitargeted kinase inhibitors.
The treatment regimen involved a combination of anti-PD-1 antibodies and autologous RetroNectin-activated cytokine-induced killer (CIK) cells.
Following the initial pseudoprogression, both patients achieved complete remission.

Findings:

Successful treatment of metastatic renal clear cell cancer was achieved using a novel immunotherapy approach.
Complete remission was observed in patients who exhibited pseudoprogression, a previously undocumented outcome.
One patient remains disease-free 1.5 years after therapy cessation.

Implications:

This study demonstrates a potential new therapeutic strategy for advanced renal clear cell cancer.
The findings suggest that pseudoprogression may be a positive indicator of treatment response in specific contexts.
Further research into combination immunotherapies involving anti-PD-1 antibodies and CIK cells is warranted for refractory cancers.