Related Experiment Video
Updated: Jan 21, 2026
07:53
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
4.7K
Light chain myeloma: A brief report from India
Neha Singh1, Narendra Agrawal2, Radhika Sekhri1
1Department of Pathology, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.
Indian Journal of Pathology & Microbiology
|July 31, 2019
Summary
Light chain myeloma (LCM) in India presents differently than in Western studies, with distinct clinical features. Indian LCM patients show comparable survival rates to other multiple myeloma subtypes, suggesting effective treatment protocols.
Area of Science:
- Hematology
- Oncology
- Clinical Research
Background:
- Light chain myeloma (LCM) accounts for 15-20% of multiple myeloma (MM) cases globally.
- Western studies link LCM to anemia, renal failure, and poorer survival, possibly due to poor differentiation.
- Understanding LCM characteristics in diverse populations is crucial for tailored treatment strategies.
Purpose of the Study:
- To investigate the clinical and hematological profiles of Indian LCM patients.
- To compare the prognostic outcomes of Indian LCM patients with IgG and IgA myeloma subtypes.
- To identify unique characteristics and survival patterns of LCM in the Indian subcontinent.
Main Methods:
- Retrospective observational study of 104 newly diagnosed multiple myeloma patients.
- Classification based on International Myeloma Working Group criteria (2016) and staging via ISS.
- Comparison of clinical data between IgG, IgA, and light chain myeloma subgroups.
Main Results:
- LCM patients showed significant correlation with hypercalcemia and elevated serum-free light chain ratios.
- IgA myeloma patients were associated with anemia and lower serum albumin levels.
- No significant differences observed in lactate dehydrogenase, renal failure, bone lesions, ISS score, chemosensitivity, or 1-year progression-free survival among subtypes.
Conclusions:
- Indian LCM patients exhibit a distinct clinico-hematological profile compared to global cohorts.
- Prognostic outcomes for Indian LCM patients are not inferior to other myeloma subtypes.
- Standardized treatment regimens may contribute to comparable survival rates in Indian LCM patients.
More Related Videos
09:41An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.5K
Related Concept Videos
01:28Electron Transport Chains
111.7K
The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
The ETC is comprised of...
111.7K
01:24Data Reporting and Recording
5.4K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.4K
01:17Radical Chain-Growth Polymerization: Chain Branching
2.4K
The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
2.4K
01:25Types of Reports I: Hands-off Report
1.5K
A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
01:30The Chain Rule
45
A system of interconnected gears provides a concrete physical interpretation of the Chain Rule in calculus. Consider three gears arranged in sequence, where the rotational speeds of the first, second, and third gears are represented by the variables x, z, and y, respectively. The first gear drives the second, and the second drives the third, so the motion of each gear depends on the one preceding it. This structure naturally leads to a two-stage variable relationship that can be analyzed using...
45
01:21Types of Reports II: Incident or Occurrence Report
1.2K
An Incident or Occurrence Report in a healthcare setting is a crucial document used to record any unexpected occurrence that may or may not have affected a patient, employee, or visitor. Such reports are critical to improving patient safety and include all details leading up to and including the event.
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
1.2K