Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between upper airway negative pressure pulses and CO2 on breathing pattern.

D L Woodall1, O P Mathew

  • 1Department of Pediatrics, University of Texas Medical Branch, Galveston 77550.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|July 1, 1988
PubMed
Summary

Negative pressure pulses applied to the upper airway inhibit inspiration, prolonging its duration. This effect on breathing pattern persists even with elevated carbon dioxide (CO2) levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spectrum of Haemoglobinopathies in a Tertiary Care Hospital of Armed Forces.

Medical journal, Armed Forces India·2016
Same author

Impact of Body Mass Index on Left Ventricular Function.

Medical journal, Armed Forces India·2016
Same author

Apnea of prematurity: pathogenesis and management strategies.

Journal of perinatology : official journal of the California Perinatal Association·2010
Same author

A case of hereditary protein S deficiency presenting with cerebral sinus venous thrombosis and deep vein thrombosis at high altitude.

Acta haematologica·2008
Same author

WPW and preexcitation syndromes.

The Journal of the Association of Physicians of India·2008
Same author

Non-sinus bradyarrhythmias in very low birth weight infants.

Journal of perinatology : official journal of the California Perinatal Association·2006

Area of Science:

  • Respiratory Physiology
  • Pulmonary Medicine
  • Anesthesiology

Background:

  • The control of breathing is complex, involving neural feedback from various respiratory system components.
  • Upper airway reflexes can significantly influence respiratory patterns, particularly during inspiration.
  • The impact of hypercapnia (elevated CO2) on these reflexes is not fully understood.

Purpose of the Study:

  • To investigate the effect of negative pressure pulses on the upper airway on breathing pattern.
  • To determine if elevated carbon dioxide levels alter the response to upper airway negative pressure stimulation.
  • To elucidate the interaction between upper airway afferents and central respiratory drive.

Main Methods:

  • Ten anesthetized, spontaneously breathing rabbits were used.

Related Experiment Videos

  • The upper airway was isolated, and negative pressure pulses (-15 cmH2O) were applied during early inspiration.
  • Breathing patterns were recorded under normoxia, hypoxia, and varying concentrations of CO2 (6% and 9%).

    • Main Results:

    • Negative pressure pulses reversibly inhibited inspiration, increasing inspiratory duration (TI).
    • Peak diaphragmatic electromyogram (Dia EMG) and expiratory duration remained unchanged.
    • Mean inspiratory drive (peak Dia EMG/TI) decreased, an effect that persisted with elevated CO2 levels.

    Conclusions:

    • Upper airway negative pressure pulses effectively alter breathing patterns by inhibiting inspiration and reducing inspiratory drive.
    • This modulatory effect on breathing is independent of the level of CO2, suggesting a robust reflex mechanism.
    • These findings contribute to understanding respiratory control and the management of respiratory disturbances.