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Updated: Jan 21, 2026
07:06
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
27.7K
[Faecal transplants for children with recurrent infections]
Rogier E Ooijevaar1,2, Tessel M van Rossen3, Christina M J E Vandenbroucke-Grauls3
1Amsterdam UMC, afd. Maag-, Darm-, en Leverziekten, Amsterdam.
Nederlands Tijdschrift Voor Geneeskunde
|July 31, 2019
Summary
Clostridioides difficile infections in children, though rare, often recur. Fecal transplants offer a safe and effective treatment for recurrent Clostridioides difficile infections in pediatric patients.
Area of Science:
- Pediatric Gastroenterology
- Infectious Diseases
- Microbiome Research
Background:
- Clostridioides difficile infection (CDI) is an uncommon cause of diarrhea in children.
- Recurrences are frequent despite standard antibiotic therapies.
- Risk factors include antibiotic exposure and impaired immunity.
Observation:
- Two pediatric cases of recurrent CDI are presented.
- A boy with a motility disorder and a girl with Down syndrome experienced multiple CDI episodes.
- These infections occurred following antibiotic use for otitis media and prolonged antibiotic/chemotherapy, respectively.
Findings:
- Both pediatric patients with recurrent CDI achieved successful resolution of infection.
- Treatment was successfully administered via fecal microbiota transplantation (FMT).
Implications:
- Fecal microbiota transplantation is a viable and effective therapeutic option for recurrent CDI in children.
- This approach may be particularly beneficial for pediatric patients with underlying conditions or complex treatment histories.
- Further research into FMT for pediatric CDI is warranted to establish broader clinical guidelines.
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