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Published on: September 10, 2018
Oocyte donation in donors with levonorgestrel intrauterine device: a good match?
Ana Galvão1, Gunes Karakus2, Annalisa Racca3
1Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Department of Obstetrics and Gynaecology, Centro Materno Infantil do Norte, Centro Hospitalar do Porto, Largo da Maternidade de Júlio Dinis 30, 4050-651 Porto, Portugal.
Research Question:
Does the levonorgestrel-releasing intrauterine device (LNG-IUD) influence cumulative live birth rate (CLBR) in oocyte donor cycles?
Design:
Retrospective cohort study based on prospectively collected data from 1 May 2009 to 31 December 2017, without attrition, consisting of 491 consecutive cycles of vitrified oocyte donation, none lost to follow-up (unique donor-recipient pairs). All donors underwent ovarian stimulation using gonadotrophin releasing hormone (GnRH) antagonist co-treatment and GnRH agonist trigger. CLBR was chosen as primary outcome measure.
Results:
In total, 103 (21.0%) cycles were carried out in donors carrying a LNG-IUD. In 388 (79.0%) cycles, no LNG-IUD was present. After confounder-adjustment, the use of an LNG-IUD did not have a statistically significant influence on CLBR.
Conclusions:
The LNG-IUD does not negatively affect CLBR.
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