ROUTINELY AVAILABLE BIOMARKERS AS LONG-TERM PREDICTORS OF DEVELOPING SYSTOLIC DYSFUNCTION IN COMPLETELY...

Area of Science:

• Cardiology
• Biomarkers in Cardiovascular Disease
• Myocardial Infarction Research

Background:

• Acute ST-segment elevation myocardial infarction (STEMI) can lead to long-term systolic dysfunction.
• Identifying predictors of reduced left ventricular ejection fraction (LVEF) is crucial for patient management.
• The role of cardiac biomarkers in predicting long-term systolic function after primary percutaneous coronary intervention (PCI) requires further investigation.

Purpose of the Study:

• To evaluate high-sensitivity C-reactive protein (hsCRP), cardiac troponin T (cTnT), and creatine kinase (CK) as long-term predictors of reduced systolic function.
• To assess these biomarkers in patients with acute STEMI, normal LVEF at admission, single-vessel disease, and complete revascularization post-primary PCI.

Main Methods:

• Prospective study of 47 acute STEMI patients with normal LVEF (≥50%) undergoing complete revascularization.
• Blood samples collected from admission to day 7.
• Primary endpoint: reduction of LVEF <50% at 12 months.

Main Results:

• Patients who developed systolic dysfunction (LVEF <50%) showed significantly higher mean cTnT at 24 hours (5.11 vs. 2.82 µg/L, p=0.010).
• Higher peak CK values were observed in patients with subsequent systolic dysfunction (3375.5 vs. 1865 U/L, p=0.008).
• No significant association was found between hsCRP levels and the development of reduced LVEF (p=0.541).

Conclusions:

• Cardiac troponin T (cTnT) and creatine kinase (CK) may serve as valuable long-term predictors of reduced left ventricular systolic function post-STEMI.
• These findings apply to STEMI patients with preserved systolic function, single-vessel disease, and complete revascularization.
• hsCRP is not a reliable long-term predictor of systolic dysfunction in this specific patient cohort.