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Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
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GENDER DIFFERENCES IN NEURODEVELOPMENTAL OUTCOMES AMONG FULL-TERM INFANTS WITH INTRAVENTRICULAR HEMORRHAGE

Valentina Matijević1, Bernarda Barbarić1, Marija Kraljević1

  • 11Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 3Croatian Institute of Public Health, Vinkovci, Croatia.

Acta Clinica Croatica
|August 1, 2019
PubMed

Insights

Intraventricular hemorrhage (IVH) in term infants is linked to neurodevelopmental outcomes, particularly with higher IVH grades. Gender did not significantly impact IVH distribution or developmental results in this study.

Area of Science:

  • Neonatal Neurology
  • Pediatric Neurodevelopment

Background:

  • Intraventricular hemorrhage (IVH) commonly affects premature infants but also occurs in up to 5% of term infants.
  • Risk factors for IVH in term infants span prenatal, perinatal, and postnatal periods, potentially impacting neurodevelopmental outcomes.
  • Term infants with risk factors for neurodevelopmental delay require careful evaluation for conditions like IVH.

Purpose of the Study:

  • To investigate the association between intraventricular hemorrhage (IVH) and neurodevelopmental outcomes in term infants.
  • To identify specific grades of IVH that correlate with adverse neurodevelopmental results in this population.
  • To examine potential gender-based differences in IVH occurrence and its impact on development.

Main Methods:

  • Retrospective study of toddlers (13-24 months) born at term (≥36 weeks).
  • Inclusion criteria: at least two risk factors for neurodevelopmental delay.
  • Comparison between 103 case patients with IVH and 63 control subjects without IVH, using ordinal logistic regression.

Main Results:

  • Neurodevelopmental outcome in term infants was significantly associated with the grade of intraventricular hemorrhage (p<0.05).
  • Higher grades of IVH (III and IV) were more prevalent in boys, but this difference was not statistically significant.
  • No statistically significant gender differences were found in IVH distribution or neurodevelopmental outcomes.

Conclusions:

  • The grade of intraventricular hemorrhage is a critical factor influencing neurodevelopmental outcomes in term infants.
  • While severe IVH showed a trend towards affecting more boys, gender did not emerge as a significant determinant for IVH or developmental prognosis.
  • Further research may be warranted to explore subtle gender-related effects and refine understanding of IVH impact in term neonates.

Keywords:
Cerebral intraventricular hemorrhageDevelopmental disabilitiesInfant, newbornInfant, prematurePsychomotor disordersRisk factors

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