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Polymer Nanocontainers for Intracellular Delivery.
Sharafudheen Pottanam Chali1, Bart Jan Ravoo1
1Organic Chemistry Institute and Centre for Soft Nanoscience, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.
Angewandte Chemie (International Ed. in English)
|August 1, 2019
Summary
Polymer nanocontainers offer improved intracellular delivery of therapeutics by overcoming issues like toxicity and low specificity. Their design combines stimuli-responsive release and targeted surface modification for enhanced therapeutic outcomes.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery
Background:
- Therapeutic agents face limitations including low specificity, systemic toxicity, rapid clearance, and poor therapeutic index.
- Effective intracellular delivery is crucial for enhancing therapeutic efficacy and minimizing side effects.
Purpose of the Study:
- To review the design and properties of polymer nanocontainers for intracellular delivery.
- To classify these nanocontainers based on their polymer architecture.
Main Methods:
- Summary of existing literature on polymer nanocontainers.
- Classification based on polymer architecture (e.g., core-shell structures).
Main Results:
- Polymer nanocontainers with aqueous cores and polymer shells are increasingly investigated.
- These nanocontainers integrate stimuli-responsive elements for controlled payload release.
- Surface modification strategies enhance target selectivity for improved intracellular delivery.
Conclusions:
- Polymer nanocontainers represent a promising platform for advanced intracellular drug delivery.
- Their tunable properties allow for overcoming major challenges in current therapeutic strategies.
- Further research into nanocontainer architecture can optimize targeted delivery and therapeutic efficacy.
Keywords:
block copolymersintracellular deliverypolymer nanocontainersstimuli-responsive materialsvesiclesMore Related Videos
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