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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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The Nucleosome Core Particle01:12

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Drug Delivery: Enteral Route01:18

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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Bioinspired Core-Shell Nanoparticles for Hydrophobic Drug Delivery.

Guangze Yang1, Yun Liu1, Haofei Wang1

  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Queensland, 4072, Australia.

Angewandte Chemie (International Ed. in English)
|August 1, 2019
PubMed
Summary
This summary is machine-generated.

New core-shell nanoparticles achieve high drug loading (up to 65%) and encapsulation efficiency (>99%) for hydrophobic drugs. This platform enhances in vitro and in vivo therapeutic effects, showcasing the importance of high drug-loading nanoparticles.

Keywords:
biomimetic synthesiscancerdrug deliverynanoparticlespeptides

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Conventional nanoparticles struggle with low drug loading capacities (<10%) for hydrophobic drugs.
  • Developing efficient drug delivery systems remains a critical challenge in pharmaceutical research.

Purpose of the Study:

  • To develop core-shell nanoparticles with exceptionally high drug loading and encapsulation efficiency for hydrophobic drugs.
  • To demonstrate the versatility and therapeutic potential of this novel nanoparticle platform.

Main Methods:

  • Fabrication of core-shell nanoparticles using modular biomolecule templating.
  • Design of bifunctional amphiphilic peptides for nanoparticle stabilization and biosilicification.
  • Formation of drug-core silica-shell nanocomposites.

Main Results:

  • Achieved exceptionally high drug loading up to 65% (w/w) and encapsulation efficiencies >99%.
  • Demonstrated the platform's versatility for various hydrophobic cargos.
  • High drug-loading nanoparticles exhibited enhanced in vitro cytotoxicity and in vivo tumor growth suppression.

Conclusions:

  • The developed core-shell nanoparticle platform offers a significant advancement in hydrophobic drug delivery.
  • High drug loading is crucial for improving therapeutic efficacy in both in vitro and in vivo settings.
  • This technology holds promise for various biomedical applications requiring efficient delivery of hydrophobic agents.