Related Experiment Video

Updated: Jan 21, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

6.2K

Glycaemic variability: The under-recognized therapeutic target in type 1 diabetes care

Emma G Wilmot1,2, Pratik Choudhary3, Lalantha Leelarathna4,5

  • 1Diabetes Department, Royal Derby Hospital, University Hospitals of Derby and Burton NHSFT, Derby, Derbyshire, UK.

Diabetes, Obesity & Metabolism
|August 1, 2019
PubMed

Insights

Managing type 1 diabetes mellitus (T1DM) is challenging. Glycaemic variability (GV), measured by continuous glucose monitoring (CGM), offers a better understanding of glucose control than HbA1c, potentially improving complication risks.

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Diabetes Management

Background:

  • Type 1 diabetes mellitus (T1DM) management is complex, with near-normal blood glucose levels difficult to achieve in practice.
  • HbA1c is the traditional marker for glucose control but is recognized as a crude measure.
  • Glycaemic variability (GV) is increasingly seen as a more relevant indicator of glucose control and complication risk.

Purpose of the Study:

  • To review the relationship between glycaemic variability (GV) and diabetes complications.
  • To explore the impact of modern diabetes technologies and therapies on GV.
  • To advocate for GV as a key metric in assessing therapeutic success for T1DM.

Main Methods:

  • Literature review of studies on glycaemic variability in Type 1 Diabetes Mellitus.
  • Analysis of the impact of continuous glucose monitoring (CGM), insulin pumps, and closed-loop systems on GV.
  • Examination of newer insulins and adjunctive therapies in relation to GV.

Main Results:

  • HbA1c is a limited measure of glucose control compared to GV.
  • Continuous glucose monitoring (CGM) enables detailed assessment of inter- and intraday GV.
  • GV is linked to hypoglycaemia and micro/macrovascular complications.

Conclusions:

  • Glycaemic variability (GV) is a crucial, yet underutilized, metric in T1DM management.
  • Emerging technologies significantly impact GV, offering new avenues for improved control.
  • Further research is needed to fully understand the benefits of reducing GV in T1DM.

Keywords:
continuous glucose monitoringglycaemic variabilitytype 1 diabetes mellitus

More Related Videos

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes05:18

A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes

Published on: February 17, 2023

5.7K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

3.2K

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.4K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
5.0K
Variables Affecting Phosphorescence and Fluorescence01:26

Variables Affecting Phosphorescence and Fluorescence

Fluorescence and phosphorescence are essential phenomena in fields like analytical chemistry, biological imaging, and materials science, where they detect molecular properties and visualize cellular structures. Understanding the variables that influence these luminescent behaviors is crucial for maximizing accuracy and efficiency in their applications. These variables can broadly be grouped into chemical structure, solvent properties, and external conditions, each playing a distinct role in...
1.3K
Variability: Analysis01:11

Variability: Analysis

Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
450
Random Variables01:09

Random Variables

A random variable is a single numerical value that indicates the outcome of a procedure. The concept of random variables is fundamental to the probability theory and was introduced by a Russian mathematician, Pafnuty Chebyshev, in the mid-nineteenth century.
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
17.5K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.2K