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Updated: Jan 21, 2026

An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Self-destructive PEG-BODIPY nanomaterials for photodynamic and photothermal therapy
Chaonan Li1, Wenhai Lin2, Shi Liu3
1Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China. weizhang@ciac.ac.cn xiez@ciac.ac.cn and University of Science and Technology of China, Hefei 230026, P. R. China.
Abstract:
Photoactive nanoparticles are an important platform for multimodal imaging and phototherapy of tumors. Herein, amphiphilic photosensitizers were made from boron dipyrromethene (BODIPY) and poly(ethylene glycol) (PEG2k) by using a thioketal linker, which is reactive oxygen species-responsive. The photosensitizers could form stable nanoparticles in aqueous solution. The resulting nanoparticles could simultaneously produce heat and reactive oxygen species upon irradiation to achieve combined photothermal and photodynamic therapy. The produced singlet oxygen could destroy the thioketal linker, and accelerate the destruction of nanoparticles. In addition, the near-infrared fluorescence and photoacoustic imaging ability of nanoparticles can reflect the biodistribution and destiny of nanoparticles. This work highlights the application of integrated diagnostic and therapeutic photosensitizers in carriers.
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