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Alendronate-Functionalized Poly(2-oxazoline)s with Tunable Affinity for Calcium Cations.

María J Sánchez-Fernández1,2, Mikey R Immers1, Rosa P Félix Lanao1

  • 1Department of Bio-Organic Chemistry, Institute for Molecules and Materials , Radboud University , 6525 AJ Nijmegen , the Netherlands.

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Summary

Novel polymers with tunable calcium cation affinity were synthesized. Alendronate-functionalized poly(2-oxazoline)s show significantly enhanced calcium binding, forming robust hydrogels for biomedical applications.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Developing polymers with specific ion-binding properties is crucial for advanced materials.
  • Poly(2-oxazoline)s offer a versatile platform for polymer functionalization.
  • Controlling cation affinity is key for applications in drug delivery and tissue engineering.

Purpose of the Study:

  • To synthesize poly(2-oxazoline)s functionalized with alendronate, hydroxyl, and carboxylic acid groups.
  • To create novel polymers with tunable affinity for calcium cations.
  • To explore the potential of these polymers in forming robust hydrogel networks.

Main Methods:

  • Synthesis of poly(2-oxazoline)s with varying functional groups.
  • Isothermal titration calorimetry to quantify calcium cation binding affinity.
  • Oscillatory rheology to assess hydrogel network properties.

Main Results:

  • Achieved tunable calcium binding affinity, with alendronate-functionalized polymers showing up to 120-fold higher affinity (K = 2.4 × 10^5 M^-1) than previously reported polymers.
  • Demonstrated linear increase in Ca2+ binding affinity with alendronate content.
  • Formed robust hydrogel networks with excellent self-recovery properties (>100% storage modulus recovery).

Conclusions:

  • Successfully synthesized poly(2-oxazoline)s with controllable alendronate functionalization for enhanced calcium binding.
  • The developed polymers exhibit strong, tunable calcium affinity and form stable, self-healing hydrogels.
  • These findings highlight the potential of alendronate-functionalized poly(2-oxazoline)s for diverse biomedical applications.