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Approach to tapering antisarcoidosis therapy.
Kamonpun Ussavarungsi1, Alicia K Gerke
1Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
Current Opinion in Pulmonary Medicine
|August 1, 2019
Summary
Sarcoidosis treatment, often with corticosteroids, can be challenging to taper due to side effects and lack of standardized guidelines. This review offers guidance for managing sarcoidosis therapy withdrawal.
Area of Science:
- Immunology
- Pulmonology
- Rheumatology
Background:
- Sarcoidosis is a multisystemic granulomatous disease with variable prognosis.
- Pulmonary involvement is common, ranging from spontaneous remission to progressive disease requiring intervention.
Purpose of the Study:
- To review current first-line corticosteroid therapy for sarcoidosis.
- To explore alternative, corticosteroid-sparing treatments.
- To provide guidance on tapering sarcoidosis therapy.
Main Methods:
- Literature review of current treatment regimens for pulmonary sarcoidosis.
- Analysis of corticosteroid efficacy and side effect profiles.
- Evaluation of evidence-based data for therapy tapering.
Main Results:
- Corticosteroids are effective initial therapy but carry significant side effects.
- Optimal corticosteroid regimens and treatment durations are not well-established.
- Current approaches to tapering sarcoidosis therapy are not standardized.
Conclusions:
- Guidance for tapering sarcoidosis therapy is provided based on existing literature.
- The review addresses challenges in managing corticosteroid side effects and treatment withdrawal.
- Further research is needed to establish evidence-based tapering protocols.
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