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Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives
Efstathia Pasmatzi1, Christina Papadionysiou1, Alexandra Monastirli2
1Department of Dermatology, School of Medicine, Patras University, Rio-Patras, Greece.
Anais Brasileiros De Dermatologia
|August 1, 2019
Summary
Galectin 3, a multifunctional protein, plays a key role in cellular processes and disease pathogenesis. This review covers its role in human skin disorders, offering insights into diagnosis, prognosis, and potential treatments.
Area of Science:
- Biochemistry
- Cell Biology
- Dermatology
Background:
- Galectin 3 is a ~31 kDa protein recognizing N-acetyl-lactosamine on glycoconjugates.
- It is expressed in various human cell types, including epithelial and myeloid cells.
- Galectin 3 is crucial for cellular processes and implicated in diverse disease pathogenetic mechanisms.
Purpose of the Study:
- To summarize current knowledge on galectin 3 expression in normal and diseased human skin.
- To explore its implications in the pathogenesis, diagnosis, and prognosis of cutaneous disorders.
- To discuss novel therapeutic strategies involving galectin 3 or its modulators for skin conditions.
Main Methods:
- Literature review of studies on galectin 3 expression and function in human skin.
- Analysis of galectin 3's role in the pathogenesis of various skin diseases.
- Evaluation of diagnostic and prognostic significance of galectin 3 in dermatology.
- Exploration of therapeutic potential of galectin 3 inhibitors/antagonists.
Main Results:
- Galectin 3 exhibits differential expression patterns in normal versus diseased human skin.
- Its involvement is noted in the pathogenesis of several cutaneous disorders.
- Galectin 3 shows potential as a diagnostic and prognostic biomarker for skin conditions.
- Targeting galectin 3 presents a promising therapeutic avenue for dermatological diseases.
Conclusions:
- Galectin 3 is a significant factor in skin biology and pathology.
- Understanding its role can improve diagnosis and prognosis of skin diseases.
- Therapeutic targeting of galectin 3 offers new treatment possibilities for cutaneous disorders.
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