Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement01:21

[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

3.4K
The Cope rearrangement is classified as a [3,3] sigmatropic shift in 1,5-dienes, leading to a more stable, isomeric 1,5-diene. The reaction involves a concerted movement of six electrons, four from two π bonds and two from a σ bond, via an energetically favorable chair-like transition state.
3.4K
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement01:24

[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement

2.8K
The Claisen rearrangement is a [3,3] sigmatropic rearrangement of allyl vinyl ethers to unsaturated carbonyl compounds. The rearrangement is a concerted pericyclic reaction proceeding via a chair-like transition state.
2.8K
Lewis Acids and Bases02:33

Lewis Acids and Bases

48.2K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.2K
Preparation of Diols and Pinacol Rearrangement01:57

Preparation of Diols and Pinacol Rearrangement

4.1K
Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.
4.1K
The Citric Acid Cycle02:36

The Citric Acid Cycle

161.5K
The citric acid cycle, also known as the Krebs cycle or TCA cycle, consists of several energy-generating reactions that yield one ATP molecule, three NADH molecules, one FADH2 molecule, and two CO2 molecules.
161.5K
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview01:07

Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview

3.6K
In the presence of an aqueous base and a halogen, primary amides can lose the carbonyl (as carbon dioxide) and undergo rearrangement to form primary amines. This reaction, called the Hofmann rearrangement, can produce primary amines (aryl and alkyl) in high yields without contamination by secondary and tertiary amines.
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycosyltransferases as Oncogenic Drivers: Lessons from Cancer Genome Mining.

DNA and cell biology·2026
Same author

Mining cancer genomes for copy number alterations identifies glycosylation enzymes as oncogenic drivers.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Shp1 phosphatase regulates CXCR2 protein stability and IL8-mediated invasiveness in breast cancer.

Cell death & disease·2026
Same author

Siamese Twins: The Multimodular Mechanisms of Golgi Maturation and Glycan Synthesis Are Coupled at Their Core.

Sub-cellular biochemistry·2026
Same author

<i>CMTM8</i> variants influence BNT162b2 COVID-19 vaccination response by regulating granulocytic/polymorphonuclear myeloid-derived suppressor cell activity.

Frontiers in immunology·2026
Same author

Improving our understanding of the biology of aging: findings from the Age-It Research Program.

The journals of gerontology. Series B, Psychological sciences and social sciences·2025

Related Experiment Video

Updated: Jan 21, 2026

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
07:49

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum

Published on: January 22, 2019

8.3K

Phosphatidic acid in membrane rearrangements.

Mikhail A Zhukovsky1, Angela Filograna1, Alberto Luini1

  • 1Institute of Protein Biochemistry and Institute of Biochemistry and Cell Biology, National Research Council, Naples, Italy.

FEBS Letters
|August 1, 2019
PubMed
Summary

Phosphatidic acid (PA), a simple lipid, influences cell membrane dynamics. Its unique properties enable it to regulate membrane fusion and fission through four key mechanisms, impacting cellular signaling and function.

Keywords:
diacylglycerollysophosphatidic acidmembrane curvaturemembrane fissionmembrane fusionphosphatidic acid

More Related Videos

Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
06:45

Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids

Published on: August 9, 2024

1.9K
Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes
10:08

Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes

Published on: December 27, 2024

790

Related Experiment Videos

Last Updated: Jan 21, 2026

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum
07:49

Spontaneous Formation and Rearrangement of Artificial Lipid Nanotube Networks as a Bottom-Up Model for Endoplasmic Reticulum

Published on: January 22, 2019

8.3K
Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
06:45

Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids

Published on: August 9, 2024

1.9K
Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes
10:08

Author Spotlight: Advancing 3D Coculture Systems with PVA-PCL Nanofibrous Membranes

Published on: December 27, 2024

790

Area of Science:

  • Biochemistry
  • Cell Biology
  • Biophysics

Background:

  • Phosphatidic acid (PA) is the simplest glycerophospholipid.
  • PA possesses unique biophysical properties: small headgroup, negative charge, and phosphomonoester group.
  • PA's charge increases upon interaction with lysine or arginine, stabilizing protein-lipid interactions.

Purpose of the Study:

  • To discuss the biophysical properties of PA.
  • To explore PA's roles in membrane fusion and fission.
  • To elucidate PA's influence on cellular signaling and membrane rearrangements.

Main Methods:

  • Literature review and theoretical discussion.
  • Analysis of PA's biochemical and biophysical characteristics.
  • Examination of PA's interactions with proteins and lipids.

Main Results:

  • PA influences membrane fusion and fission via four mechanisms.
  • PA acts as a substrate for lipid-modifying enzymes.
  • PA contributes to membrane curvature and interacts with key proteins.
  • PA activates enzymes involved in membrane rearrangements.

Conclusions:

  • PA's biophysical properties are central to its diverse cellular functions.
  • PA plays a critical role in regulating membrane dynamics, fusion, and fission.
  • Understanding PA's properties is key to comprehending cellular signaling and membrane organization.