Cochlear-Vestibular Impairment due to West Nile Virus Infection

West Nile virus (WNV) has been spreading over the last 20 years. Human infection is asymptomatic in most cases. When the disease becomes clinically manifest, it may involve a range of issues, from a mild infection with flu-like symptoms to a neuroinvasive disease. Albeit rarely, WNV-associated sensorineural hearing loss (SNHL) has also been reported. Here we describe two new cases of SNHL and balance impairment caused by WNV infection.

The patients were investigated with repeated audiometric tests and, for the first time, videonystagmography was also used.

Unlike findings in the few other published cases, an improvement in audiometric thresholds and vestibular function was documented in both of our patients.

In the light of our findings, a prospective study would be warranted on a large series of patients with WNV infection in order: (i) to better define the epidemiology of the related cochlear-vestibular involvement; and (ii) to elucidate the virus-related changes to peripheral and central auditory and vestibular functions.