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Updated: Jan 21, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Years of Potential Life Lost from Cardiovascular Disease Among Hispanics
Lakshman Manjunath1, Jiaqi Hu2, Latha Palaniappan3
1Department of Internal Medicine, Stanford University, Stanford, CA.
Insights
Puerto Ricans face higher premature cardiovascular mortality than Mexicans and Cubans. Tailoring public health strategies to Hispanic subgroups is crucial for improving cardiovascular health outcomes.
Area of Science:
- Public Health
- Cardiovascular Epidemiology
- Health Disparities
Background:
- Cardiovascular disease (CVD) is a leading cause of premature death.
- Hispanic populations in the U.S. are diverse, with varying health profiles.
- Understanding CVD mortality across Hispanic subgroups is essential for targeted interventions.
Purpose of the Study:
- To quantify the impact of cardiovascular disease and its subtypes on premature mortality among distinct Hispanic subgroups in the U.S.
- To analyze disparities in cardiovascular disease mortality across Mexican, Puerto Rican, and Cuban populations.
- To identify specific CVD subtypes contributing most to premature mortality within these groups.
Main Methods:
- Utilized national death records from 2003-2012 for over 832,550 deaths.
- Identified cardiovascular disease deaths and subtypes (ischemic, cerebrovascular, hypertensive, heart failure) using ICD-10 codes.
- Calculated Years of Potential Life Lost (YPLL) standardized to the 2000 U.S. Census population.
Main Results:
- Puerto Ricans exhibited the highest YPLL for overall cardiovascular disease (1,139 YPLL/100,000) compared to Mexicans (868) and Cubans (841).
- This disparity in premature cardiovascular mortality persisted over the decade studied.
- Puerto Ricans had the highest YPLL for ischemic and hypertensive heart disease; Mexicans led in cerebrovascular disease mortality.
Conclusions:
- Disaggregating data by Hispanic subgroup reveals significant heterogeneity in premature cardiovascular mortality.
- Public health strategies must incorporate Hispanic subgroup status to effectively address cardiovascular health.
- Targeted interventions are needed to reduce CVD disparities among diverse Hispanic populations.
Objective:
To quantify the impact of cardiovascular disease and its subtypes on the premature mortality of Hispanics in the United States.
Methods:
We used national death records to identify deaths for the three largest Hispanic subgroups (Mexicans, Puerto Ricans, and Cubans) in the United States from 2003 to 2012 (N = 832,550). We identified all deaths from cardiovascular disease and by subtype (ie, ischemic, cerebrovascular, hypertensive and heart failure) using the underlying cause of death via ICD-10 codes. Years of potential life lost (YPLL) was calculated by age categories standardizing with the 2000 US Census population. Population estimates were calculated using linear interpolation from 2000 and 2010 US Census data.
Results:
After standardization, Puerto Ricans experienced the highest YPLL for all types of cardiovascular disease compared with Mexicans and Cubans (1,139 years per 100,000 compared with 868 and 841, respectively), a disparity that remained consistent over the course of a decade. Among different subcategories of cardiovascular disease, Puerto Ricans had the highest YPLL for ischemic and hypertensive heart disease, while Mexicans had the highest YPLL from cerebrovascular disease.
Conclusions:
In conclusion, disaggregation of Hispanic subgroups revealed marked heterogeneity in premature cardiovascular mortality. These findings suggest that measures to improve the cardiovascular health of Hispanics should incorporate subgroup status as a key part of public health strategy.
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