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The study protocol for the China Health Big Data (China Biobank) project
Yan Wu1, Zhe Guo2, Xiaoxia Fu3
1Department of Radiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Quantitative computed tomography (QCT) analysis of low-dose chest computed tomography (LDCT) scans can accurately measure bone density, visceral fat, and liver fat. This enables large-scale health assessments for osteoporosis, obesity, and fatty liver disease.
Area of Science:
- Radiology and Imaging
- Public Health
- Biomedical Data Science
Background:
- Osteoporosis, obesity, and fatty liver are prevalent chronic diseases impacting global health.
- Low-dose chest computed tomography (LDCT) is standard for lung cancer screening.
- Quantitative computed tomography (QCT) can derive bone mineral density, liver fat, and abdominal fat from existing LDCT data without additional radiation.
Purpose of the Study:
- To investigate the added value of QCT analysis to LDCT scans in a large Chinese cohort.
- To establish normative reference databases and diagnostic criteria for osteoporosis, obesity, and fatty liver disease.
- To leverage existing LDCT data for comprehensive health assessments.
Main Methods:
- The China Biobank project is a prospective, nationwide, multicenter cohort study.
- Participants (30-90 years) undergo LDCT as part of routine health checkups.
- QCT analysis software (QCT PRO v6.0) measures volumetric bone mineral density (vBMD), visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat content.
Main Results:
- The integration of QCT with LDCT for chest scans has been successfully validated.
- Volumetric bone mineral density (vBMD) of the spine, visceral fat, and liver fat can be reliably measured from LDCT chest scans.
Conclusions:
- The China Biobank project demonstrates the utility of QCT analysis on LDCT scans.
- This approach allows for accurate evaluation of osteoporosis, obesity, and fatty liver disease prevalence in a large Chinese population.
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