Related Experiment Video

Updated: Jan 21, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

9.1K

Anticancer Activity of Dinitrosyl Iron Complex (NO Donor) on the Multiple Myeloma Cells

N P Akentieva1,2, N A Sanina3,4, T R Prichodchenko3

  • 1Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia. na_aken@icp.ac.ru.

Doklady. Biochemistry and Biophysics
|August 2, 2019
PubMed

Insights

A novel dinitrosyl iron complex (DNIC7) demonstrated cytotoxic effects against multiple myeloma cells. This compound reduced cell viability and proliferation, suggesting potential as a cancer therapeutic.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Oncology

Background:

  • Multiple myeloma is a cancer of plasma cells.
  • Developing novel therapeutic agents is crucial for cancer treatment.
  • Dinitrosyl iron complexes (DNICs) are being investigated for their biological activities.

Purpose of the Study:

  • To investigate the effect of a mononuclear dinitrosyl iron complex (DNIC7) on multiple myeloma cells.
  • To determine the cytotoxic properties and underlying mechanisms of DNIC7.

Main Methods:

  • Cell viability assays were performed.
  • Cell proliferation was measured.
  • Fluorescent analysis was used to assess intracellular glutathione and reactive oxygen species levels.

Main Results:

  • DNIC7 significantly decreased the viability of multiple myeloma cells.
  • DNIC7 inhibited the proliferation of multiple myeloma cells.
  • DNIC7 treatment led to decreased intracellular glutathione and increased reactive oxygen species.

Conclusions:

  • DNIC7 exhibits cytotoxic properties against multiple myeloma cells.
  • The mechanism involves modulation of redox balance.
  • DNIC7 shows therapeutic potential for cancer treatment.

More Related Videos

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma07:53

Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma

Published on: April 15, 2022

4.7K
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis10:04

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis

Published on: May 1, 2015

13.5K

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.7K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
38.0K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
25.8K
Multiple Regression01:25

Multiple Regression

Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.8K
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
25.8K