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New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling

Jian He1, Hui Wang1, Jan Vijg1

  • 1Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, P. R. China.

Chemistry & Biodiversity
|August 2, 2019
PubMed

Insights

Traditional Chinese Medicines (TCMs) show promise in treating type 2 diabetes by improving insulin resistance. Further research into their bioactive compounds can lead to new drug development for metabolic diseases.

Area of Science:

  • Pharmacology
  • Metabolic Diseases
  • Traditional Chinese Medicine

Background:

  • Type 2 diabetes is a significant metabolic disease linked to insulin resistance.
  • Insulin resistance is a key factor in type 2 diabetes, hypertension, hyperlipidemia, and coronary heart disease.
  • Traditional Chinese Medicines (TCMs) are recognized for their role in managing type 2 diabetes, but their mechanisms require further elucidation.

Purpose of the Study:

  • To review recent advancements in understanding the pharmacological mechanisms of TCM bioactive ingredients.
  • To explore the therapeutic potential of TCM compounds in treating diabetic insulin resistance.
  • To provide references for developing novel TCM-derived drugs for diabetes and insulin resistance.

Main Methods:

  • Literature review of recent scientific progress.
  • Focus on bioactive ingredients from TCMs with diverse functional groups.
  • Analysis of studies demonstrating therapeutic effects on insulin resistance.

Main Results:

  • Identified various bioactive ingredients from TCMs with potential to treat insulin resistance.
  • Highlighted the diverse functional groups present in these compounds.
  • Summarized recent progress in understanding their pharmacological actions.

Conclusions:

  • Bioactive compounds from TCMs offer promising therapeutic strategies for type 2 diabetes and insulin resistance.
  • Elucidating mechanisms of TCMs is crucial for their modernization and drug development.
  • This review provides a foundation for future research into TCM-derived antidiabetic drugs.
Keywords:
bioactive compoundsinsulin resistancemetabolic syndrometraditional Chinese medicinestype 2 diabetes

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