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Unprecedented 4/7 Bicyclic Carbon Skeleton Sesquiterpenoids With Anti-Inflammatory Activities Isolated From the Root
Yuqian Tang1, Yingming Luo1, Chuxing Liang1
1State Key Laboratory of Traditional Chinese Medicine Syndrome, International Institute for Translational Chinese Medicine, Key Laboratory of Chinese Medicinal Resource from Lingnan, Key Laboratory of Chronic Disease Prevention and Control of Traditional Chinese Medicine of Guangdong Higher Education Institutes, Ministry of Education, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Abstract:
Six new sesquiterpenoids glasesquiterpenoids A-F (1-6), together with two known ones, 7 and 8, were coisolated from the root of Lindera glauca. Their structures were elucidated by x-ray diffraction, quantum chemical calculations, and spectroscopic methods. Glasesquiterpenoid A (1) with an unprecedented 4/7 bicyclic carbon skeleton was the first example reported in the class of sesquiterpenoids. In the bioassays, compounds 6‒8 exhibited good inhibitory activity of NO production with IC50 values of 2.4, 5.5, and 4.0 µM, respectively, comparable to the positive control indomethacin (IC50 = 24.1 µM).
