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Biatrial Remodeling in Patients with Cystic Fibrosis Running Title: Atrial Function in Cystic Fibrosis

Aleksandar Dordevic1, Martin Genger1, Carsten Schwarz2

  • 1Department of Internal Medicine and Cardiology, Charité-University-Medicine Berlin, Campus Virchow Klinikum (CVK), 13353 Berlin, Germany.

Journal of Clinical Medicine
|August 3, 2019
PubMed

Insights

Cystic fibrosis (CF) patients show enlarged left and right atria (LA and RA), with impaired LA function. Atrial enlargement predicts mortality in CF, though lung function is the independent predictor.

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Imaging

Background:

  • Previous research on cystic fibrosis (CF) focused on ventricular remodeling, neglecting atrial function.
  • Atrial function in CF patients remains understudied.

Purpose of the Study:

  • To investigate left atrial (LA) and right atrial (RA) function in CF patients.
  • To compare atrial function between CF patients and healthy controls.

Main Methods:

  • Retrospective study of 82 CF patients and 32 controls.
  • Echocardiographic examination with strain analysis.
  • Offline, blinded analysis of echocardiographic data.

Main Results:

  • CF patients exhibited significantly higher LA and RA volume indexes compared to controls.
  • LA conduit and reservoir functions were significantly impaired in CF patients.
  • LA and RA enlargement predicted mortality, but only forced vital capacity (FVC) was an independent predictor.

Conclusions:

  • CF patients present with enlarged atria and impaired LA function.
  • LA reservoir and conduit functions are particularly deteriorated in CF.
  • Atrial enlargement is a mortality predictor in CF, with a trend of worsening function from controls to non-survivors.
Abstract

Keywords:
cystic fibrosisfunctionleft atriumright atriumstrain

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