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Subconjunctival Administration of Adeno-associated Virus Vectors in Small Animal Models

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Published on: March 16, 2022

Yellow subconjunctival deposits.

Ofira Zloto^1,2, Mordechai Rosner^1,2, Vicktoria Vishnevskia-Dai^1,2

¹The Ocular Oncology and Autoimmune Service , The Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.

BMJ Case Reports

|August 3, 2019

Summary

This summary is machine-generated.

This case report highlights a rare instance of conjunctival amyloidosis, a condition involving abnormal protein deposits in the eye. Early recognition is crucial to prevent potential systemic amyloidosis diagnosis.

Keywords:

eye ophthalmology pathology

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Area of Science:

Ophthalmology
Pathology

Background:

Conjunctival amyloidosis is a rare condition characterized by amyloid protein deposition in the conjunctiva.
It is often overlooked and can be a precursor to systemic amyloidosis.

Observation:

A case report details a healthy male patient presenting with subconjunctival yellow lesions during a routine eye exam.
Histopathological examination confirmed amyloidosis as the cause of these lesions.

Findings:

The patient showed no recurrence or new lesions during a one-year follow-up period.
Importantly, there was no evidence of systemic amyloidosis involvement.

Implications:

This case highlights the importance of recognizing conjunctival amyloidosis as a distinct entity.
Timely diagnosis of ocular amyloidosis may aid in the early detection of potentially serious systemic amyloidosis.
Increased awareness among clinicians is essential for prompt diagnosis and management.