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Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
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Retinal Detachment Model in Rodents by Subretinal Injection of Sodium Hyaluronate
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Risk Factors and Individualized Risk Stratification for Sequential Bilateral Rhegmatogenous Retinal Detachment.

Mattan Arazi1,2,3, Shira Shapira Nass2, Basel Igabriye1,4

  • 1Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Tel-Aviv University, Tel-Aviv, Israel.

Retina (Philadelphia, Pa.)
|April 30, 2026
PubMed
Summary
This summary is machine-generated.

About 12.5% of patients with rhegmatogenous retinal detachment (RD) experience fellow-eye detachment. Risk is higher in younger, highly myopic males, emphasizing the need for risk-stratified surveillance.

Keywords:
Bilateral Retinal DetachmentSequential Retinal Detachmentlaser retinopexyretinal detachment

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Area of Science:

  • Ophthalmology
  • Retinal Detachment Research
  • Myopia Studies

Background:

  • Rhegmatogenous retinal detachment (RD) can affect one or both eyes.
  • Understanding predictors of fellow-eye involvement is crucial for patient management.
  • Sequential bilateral RD poses a significant risk to vision.

Purpose of the Study:

  • To identify predictors of sequential bilateral rhegmatogenous retinal detachment (RD).
  • To quantify the patient-level risk of fellow-eye involvement after unilateral RD.
  • To inform risk-stratified surveillance strategies.

Main Methods:

  • Retrospective analysis of 1,480 adult patients undergoing RD repair (2010-2023).
  • Comparison of demographic and clinical characteristics between unilateral and bilateral RD cases.
  • Multivariable logistic regression to identify predictors; probability generation based on axial length, age, and sex.

Main Results:

  • 12.5% of patients developed sequential bilateral RD.
  • Younger age, male sex, and longer axial length were significant predictors.
  • Axial length was the strongest predictor (OR 1.17 per mm increase); risk concentrated in younger, highly myopic individuals.
  • Over one-third of fellow-eye detachments were macula-off at presentation.

Conclusions:

  • Approximately 1 in 8 patients with unilateral RD develop fellow-eye detachment.
  • Risk is strongly associated with axial length, particularly in younger, myopic patients.
  • Findings support risk-stratified surveillance using readily available clinical measurements.